Fresh analysis indicates that people who discontinue popular weight-loss injections like semaglutide or tirzepatide may regain shed pounds much more quickly than those who stop traditional diet and exercise plans.
Findings released in a leading health publication points out that while overweight people frequently drop substantial amounts of their total mass while on the medication, the weight comes back at an average rate of nearly a kilo each month once they quit.
"Individuals purchasing such drugs should be aware of the risk of rapid rebound weight gain when the therapy concludes," warns lead investigator Dr. Susan Jebb.
This pace of regain suggests a return to starting weight in about a year and a half.
Comparing Treatments
The research, which examined dozens of studies involving thousands of patients, compared the effects of these new drugs with other pills.
The team emphasize that individuals who lose weight through dieting generally have a slower weight regain—approximately 100 grams monthly—once they finish.
The Reason for the Quick Rebound
Experts believe the way of the injections accounts for the accelerated rebound.
GLP-1 drugs imitate a body's own chemical called GLP-1, which moderates appetite.
"Artificially providing GLP-1 levels far above than the body's typical production may cause the body to produce less of its endogenous GLP-1, and could reduce responsiveness to its actions," noted Dr. Adam Collins, a dietetics specialist.
"Stopping of this medication results in appetite is no longer kept in check, making binge eating a significant risk."
A Chronic Disease?
Medical guidelines suggest the injections for people with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
Many experts contend that, given the high risk of weight regain, the treatment should be considered ongoing.
This perspective is supported by pharmaceutical companies, who state that the results "emphasize the persistent character of excess weight," comparing it to managing conditions like high blood pressure.
Patient Experiences
Individuals who have come off the jabs report a sudden resurgence of hunger.
"It was like a switch that goes on and you're instantly extremely hungry," recalled an individual.
This challenge is exacerbated if users have not developed lasting lifestyle or habit changes during therapy.
Significant Interest
Figures suggest that millions of people in the UK have used these injections in the last 12 months, with interest remaining high.
- Adoption is higher among women compared to men.
- The 40s and 50s age group shows the greatest level of interest.
- Many obtain the medications through private prescriptions rather than public health services.
Ultimately, experts caution that while these medications are potent agents for shedding pounds, they are not a standalone fix and maintained weight loss hinges on integrated behavioural changes.
